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Publikationen


Rezensierte Zeitschriften

Große Ruse M, Ritz C, Hothorn LA (2016): Simultaneous inference of a binary composite endpoint and its components, J, Biopharm Statist
DOI: 10.1080/10543406.2016.1148704

Hothorn LA (2016): The two-step approach - a significant ANOVA F-test before Dunnett's comparisons against a control - is not recommended, Communications in Statistics - Simulation and Computation

Kitsche A, Ritz C, Hothorn LA (2016): A General Framework for the Evaluation of Genetic Association Studies Using Multiple Marginal Models, Hum Hered 81:150-172
DOI: 10.1159/000448477

Pallmann P, Hothorn LA (2016): Analysis of means (ANOM): a generalized approach using R, Journal of Applied Statistics
DOI: 10.1080/02664763.2015.1117584

Santiago J, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M (2016): Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission, eLife
DOI: http://dx.doi.org/10.7554/eLife.15075

Baeßler, B., Schaarschmidt, F., Dick, A., Stehning, C., Schnackenburg, B., Michels, G., Maintz, D., Bunck, A.C.  (2015): Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping, Journal of Cardiovascular Magnetic Resonance. 17:115
DOI: 10.1186/s12968-015-0217-y

Baeßler, B., Schaarschmidt, F., Schnackenburg, B., Stehning, C., Giolda, A., Maintz, D, Bunck, A.C. (2015): Cardiac T2-mapping using a fast gradient echo spin echo sequence - first in vitro and in vivo experiences, Journal of Cardiovascular Magnetic Resonance. 17:67
DOI: 10.1186/s12968-015-0177-2

Bredemeier, B., von Haaren, C., Rüter, S., Schaarschmidt, F., Reich, M. (2015): Spatial congruence between organic farming and biodiversity related landscape features in Germany, International Journal of Biodiversity Science, Ecosystem Services & Management 11(4) 330-340
DOI: 10.1080/21513732.2015.1094515

Karanja J, Poehling HM, Pallmann P (2015): Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter in the control of whiteflies Aleyrodes proletella and Trialeurodes vaporariorum, accepted for publication in Journal of Economic Entomology

Kitsche A, Schaarschmidt F (2015): Analysis of Statistical Interactions in Factorial Experiments, Journal of Agronomy and Crop Science 201(1): 69-79.
DOI: 10.1111/jac.12076

Konietschke F, Placzek M, Schaarschmidt F, Hothorn LA (2015): nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals, Journal of Statistical Software 46, 9

Matthies, S., Rüter, S., Prasse, R., Schaarschmidt, F.  (2015): Factors driving the vascular plant species richness in urban green spaces: Using a multivariable approach, Landscape and Urban Planning
DOI: 10.1016/j.landurbplan.2014.10.014

Pallmann P, Hothorn LA (2015): Boxplots for grouped and clustered data in toxicology, Arch Tox
DOI: 10.1007/s00204-015-1608-4

Radespiel, U., Schaber, K., Kessler, S.E., Schaarschmidt, F., Strube, C. (2015): Variations in the excretion patterns of helminth eggs in two sympatric mouse lemur species (Microcebus murinus and M. ravelobensis) in northwestern Madagascar, Parasitology Research 114 (3): 941-954.
DOI: 10.1007/s00436-014-4259-0

Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA (2015): Statistical approaches for the determination of cut points in anti-drug antibody bioassays, Journal of Immunological Methods 418, 84–100
DOI: 10.1016/j.jim.2015.02.004

Schaarschmidt F, Hofmann M, Jaki T, Grün B, Hothorn LA  (2015): Statistical approaches for the determination of cut points in anti-drug antibody bioassays, Journal of Immunological Methods
DOI: 10.1186/s12968-015-0177-2

Weese A, Pallmann P, Papenbrock J, Riemenschneider A (2015): Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack, Frontiers in Plant Science, 6:9

Bohne H, Wanjiku J, Rathke A-K, Humpert S, Gerhard D (2014): Influence of Nutrient Loading on Growth, N-, P-, and K-Concentrations and Outplanting Performance of Rosa majalis, European Journal of Horticultural Science 79(1):29-35

Gerhard D (2014): Simultaneous Small Sample Inference For Linear Combinations Of Generalized Linear Model Parameters, Communications in Statistics - Simulation and Computation. Accepted Author Version, DOI:10.1080/03610918.2014.895836

Gerhard D, Bremer M, Ritz C (2014): Estimating marginal properties of quantitative real-time PCR data using nonlinear mixed models., Biometrics 70(1):247-254, DOI: 10.1111/biom.12124

Graf N, Dinkel B, Rose H, Hothorn LA, Gerhard D, Johansen P, Kundig TM, Klimek L, Senti G (2014): A critical appraisal of analyzing nasal provocation test results in allergen immunotherapy trials., Rhinology 52(2):137-141, DOI: 10.4193/Rhin

Hothorn LA (2014): Statistical evaluation of toxicological bioassays –a review, Toxicology Research 3:418-432 DOI: 10.1039/c4tx00047a

Jaki Th, Kitsche A, Hothorn LA (2014): Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group, JP Journal of Biostatistics 11(1):1-32

Kitsche A, Hothorn LA (2014): Testing for qualitative interaction using ratios of treatment differences, Statistics in Medicine 33(9):1477-1489 doi: 10.1002/sim.6048

Kuiper RM, Gerhard D, Hothorn LA (2014): Identification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection Approach, Statistics in Biopharmaceutical Research 6(1):55-66, DOI:10.1080/19466315.2013.847384

Pallmann P (2014): Book review: Applied meta-analysis with R, Journal of Applied Statistics 42(4): 914-915

Pallmann P, Hothorn LA, Djira GD (2014): A Levene-type test of homogeneity of several variances against ordered alternatives, Computational Statistics 29(6): 1593-1608

Schaarschmidt F and Hothorn LA (2014): Statistical Methods and Software for Validation Studies on New In Vitro Toxicity Assays, ATLA: Alternatives to Lab Animals 42:319-329

Hasler M, Hothorn LA (2013): Simultaneous confidence intervals on multivariate non-inferiority, Statistics in Medicine, 32(10) 1720-1729, DOI: 10.1002/sim.5633

Herberich E, Hothorn LA (2013): A Maximum-Type Association Test for Censored Time-to-Event Data, Journal of Biometrics & Biostatistics, 4: 178. doi: 10.4172/2155-6180.1000178

Hothorn LA, Reisinger K, Wolf T, Poth A, Fieblinger D, Liebsch M, Pirow R (2013): Statistical analysis of the hens egg test for micronucleus induction (HET-MN Assay), Mutation Research, 757:68-78

Jaki T, Hothorn LA (2013): Statistical evaluation of toxicological assays: Dunnett or Williams test- take both, Archives of Toxicology, 87:1901-1910

Jaki T, Pallmann P, Wolfsegger MJ (2013): Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs, Statistics in Medicine 32(30): 5469-5483

Jaki T, Pallmann P, Wolfsegger MJ (2013): Authors' reply to Comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs", Statistics in Medicine 32(30): 5487-5488

Kitsche A, Kalesse M (2013): Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase Domain, ChemBioChem 14(7):851-61. doi: 10.1002/cbic.201300063

Konietschke F (2013): Nparcomp-, Journal of Statistical Software, accepted

Konietschke F, Bösiger S, Brunner E, Hothorn LA (2013): Are Multiple Contrasts Tests superior to the ANOVA?, International Journal of Biostatistics, DOI 10.1515/ijb-2012-0020

Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn LA, Bremer S, van Thriel C, Krause K-H, Hengstler JG, Rahnenführer J (2013): Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach, Archives of Toxicology 87(1):123-143, DOI 10.1007/s00204-012-0967-3

Loley C, König I, Hothorn LA, Ziegler A (2013): A unifying framework for robust association testing,estimation, and genetic model selection using the generalized linear model, European Journal of Human Genetics 21, 12; 1442-1448 DOI: 10.1038/ejhg.2013.62

Priesnitz, K.-U., Benker, U., Schaarschmidt, F. (2013): Assessment of the potential impact of a Bt maize hybrid expressing Cry3Bb1 on ground beetles (Carabidae), Journal of Plant Diseases and Protection 120 (3), 131–140.

Ritz C, Gerhard D, Hothorn LA (2013): A unified framework for benchmark dose estimation applied to mixed models and model averaging, Statistics in Biopharmaceutical Research 5(1):79-90, DOI:10.1080/19466315.2012.757559

Schaarschmidt, F. (2013): Simultaneous confidence intervals for multiple comparisons among expected values of log-normal variables, Computational Statistics and Data Analysis 58, 265–275.
DOI: 10.1016/j.csda.2012.08.011

Scherer, R., Schaarschmidt, F., Prescher, S., Priesnitz, K.U. (2013): Simultaneous confidence intervals for comparing biodiversity indices estimated from overdispersed count data, Biometrical Journal 55 (2), 246–263
DOI: 10.1002/bimj.201200157

Schlingmann, B., Schadzek, P., Hemmerling, F., Schaarschmidt, F., Heisterkamp, A., Ngezahayo, A. (2013): The role of the C-terminus in functional expression and internalization of rat connexin46 (rCx46), Journal of Bioenergetics and Biomembranes, 45, 59–70.
DOI: 10.1007/s10863-012-9480-x

Bohne H, Kluge K, Amha Y, Gerhard D (2012): Influence of peats of different origins and decomposition degree on germination and early growth of Chinese cabbage, European Journal of Horticultural Science 77(5):211-218

Hasler M and Hothorn LA (2012): A multivariate Williams-type trend procedure, Statistics in Biopharmaceutical Research 4:57-65

Hasler M and Hothorn LA (2012): Simultaneous confidence intervals on multivariate non-inferiority, Statistics in Medicine (Epub ahead of print)

Herberich E and Hothorn LA (2012): Statistical evaluation of mortality in long-term carcinogenicity bioassays using a Williams-type procedure, Regulatory Toxicology and Pharmacology 64(1):26-34

Hoffmann S, Hothorn LA, Edler L, Kleensang A, Suzuki M, Phrakonkham P, Gerhard D (2012): Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay data, Mutation Research - Genetic Toxicology and Environmental Mutagenesis 744(1):36-41

Hothorn LA, Libiger O, Gerhard D (2012): Model-specific tests on variance heterogeneity for detection of potentially interacting genetic loci, BMC Genetics 13:59

Kitsche A, Schaarschmidt F, Hothorn LA (2012): The use of historical controls in estimation of simultaneous confidence intervals for comparisons against a concurrent control, Computational Statistics and Data Analysis 56(12):3865-3875 doi:10.1016/j.csda.2012.05.010

Konietschke F and Hothorn LA (2012): Evaluation of toxicological studies using a non-parametric Shirley-type trend test for comparing several dose levels with a control group, Statistics in Biopharmaceutical Research 4:14-27

Konietschke F, Hothorn LA, Brunner E (2012): Rank-based multiple test procedures and simultaneous confidence intervals, Electronic Journal of Statistics 6:737-758

Konietschke F, Libiger O, Hothorn LA (2012): Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is Unknown, PLoS ONE 7(2):e31242

Pallmann P, Schaarschmidt F, Hothorn LA, Fischer C, Nacke H, Priesnitz KU, Schork NJ (2012): Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices, Molecular Ecology Resources 12(6): 1068-1078

Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, Steiner M, Hothorn LA, Grönlund H, Tivig C, Zaleska A, Soyer O, van Hage M, Akdis CA, Akdis M, Rose H, Kündig TM (2012): Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections, Journal of Allergy and Clinical Immunology 129(5):1290-1296

Strohmaier J, Amelang M, Hothorn LA, Witt SH, Nieratschker V, Gerhard D, Meier S, Wüst S, Frank J, Loerbroks A, Rietschel M, Stürmer T, Schulze TG (2012): The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population, Molecular Psychatry 18(5):607-613, DOI:10.1038/mp.2012.53

Bohne H, Salomon L, Gerhard D (2011): Influence of provenance and fertilization in the tree nursery on outplanting performance and N-, P-, and K-content of Viburnum opulus L. in shoots and roots, Journal of Environmental Horticulture 29(3):137-142

Bunck AC, Kröger J-R, Juettner A, Brentrup A, Fiedler B, Schaarschmidt F, Crelier G, Schwindt W, Heindel W, Niederstadt T, Maintz D (2011): Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal, European Radiology 21, 1788–1796

Hasler M and Hothorn LA (2011): A Dunnett-Type Procedure for Multiple Endpoints, The International Journal of Biostatistics 7(1):1-15

Hirotsu C, Yamamoto S, Hothorn LA (2011): Estimating the Dose-Response Pattern by the Maximal Contrast Type Test Approach, Statistics in Biopharmaceutical Research 3:40-53

Hothorn LA and Djira GD (2011): A ratio-to-control Williams-type test for trend, Pharmaceutical Statistics 10(4):289-292

Selig M, Bohne H, Gerhard D (2011): Influence of refertilization of Salix cinerea L. in late summer on early frost hardiness and on some nutrients and biomarker, Gesunde Pflanzen 63(3):129-133

Bilder CR, Zhang B, Schaarschmidt F, Tebbs JM  (2010): binGroup: A Package for Group Testing, The R Journal 2/2, 56-60

Djira GD, Schaarschmidt F, Fayissa B  (2010): Inferences for Selected Location Quotients with Applications to Health Outcomes, Geographical Analysis 42:288-300

Gerhard D and Hothorn LA (2010): Rank transformation in Haseman-Elston regression using scores for location-scale alternatives, Human Heredity 69(3):143-151

Hothorn LA and Vohr HW (2010): Statistical Evaluation of the Local Lymph Node Assay, Regulatory Toxicology and Pharmacology 56(3):352-356

Hothorn LA, Sill M, Schaarschmidt F (2010): Evaluation of Incidence Rates in Pre-Clinical Studies Using a Williams-Type Procedure, The International Journal of Biostatistics 6(1): Article 15

Konietschke F, Bathke AC, Hothorn LA, Brunner E (2010): Testing and estimation of purely nonparametric effects in repeated measures designs, Computational Statistics and Data Analysis 54:1895-1905

Menke S and Gerhard D (2010): Detection of a related difference in efficacy of azadirachtin treatments for the control of whiteflies on Gerbera jamesonii by testing for interactions in generalised linear models, Pest Management Science 66(4):358-364

Rauschen S, Schaarschmidt F, Gathmann A (2010): Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize, Transgenic Research 19:727-744

Rauschen S, Schultheis E, Hunfeld H, Schaarschmidt F, Schuphan I, Eber S (2010): Diabrotica-resistant Bt-maize DKc5143 event MON88017 has no impact on the field densities of the leafhopper Zyginidia scutellaris, Environmental Biosafety Research 9, 87–99

Zimmermann H, Gerhard D, Dingermann T, Hothorn LA (2010): Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallel in vitro bioassays, Biotechnology Journal 5(1):62-74

Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010): An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 1, Pharmazeutische Industrie 72(4):708-712

Zimmermann H, Gerhard D, Hothorn LA, Dingermann T (2010): An Alternative to Animal Experiments in the Quality Control of Erythropoietin Part 2, Pharmazeutische Industrie 72(5):884-895

Acutis M, Hothorn LA, McNicol J, van der Voet H (2009): Statistical considerations for the safety evaluation of GMOs, EFSA Journal 1250:1

Dette H, Trampisch M, Hothorn LA (2009): Robust Designs in Noninferiority Three-Arm Clinical Trials With Presence of Heteroscedasticity, Statistics in Biopharmaceutical Research 1(3):268-278

Djira GD and Hothorn LA (2009): Detecting Relative Changes in Multiple Comparisons with an Overall Mean, Journal of Quality Technology 41(1):60-65

Hothorn LA and Gerhard D (2009): Statistical evaluation of the in vivo micronucleus assay, Archives of Toxicology 83(6):625-634

Hothorn LA and Hothorn T (2009): Order-restricted Scores Test for the Evaluation of Population based Case–control Studies when the Genetic Model is Unknown, Biometrical Journal 51(4):1-11

Hothorn LA, Gerhard D, Hofmann M (2009): Parametric and non-parametric prediction intervals based phase II control charts for repeated bioassay data, Biologicals 37(5): 323-330

Hothorn LA, Vaeth M, Hothorn T (2009): Trend tests for the evaluation of exposure-response relationships in epidemiological exposure studies, Epidemiologic Perspectives & Innovations 6:1

Perry JN, ter Braak CJF, Dixon PM, Duan JJ, Hails RS, Huesken A, Lavielle M, Marvier M, Scardi M, Schmidt K, Tothmeresz B, Schaarschmidt F, van der Voet H (2009): Statistical aspects of environmental risk assessment of GM plants for effects on non-target organisms, Environmental Biosafety Research 8:65-78

Schaarschmidt F, Biesheuvel E, Hothorn LA (2009): Asymptotic Simultaneous Confidence Intervals for Many-to-One Comparisons of Binary Proportions in Randomized Clinical Trials, Journal of Biopharmaceutical Statistics 19:292-310

Schaarschmidt F, Vaas L (2009): Analysis of trials with complex treatment structure using multiple contrast tests, HortScience 44(1):188-195

Braat S, Gerhard D, Hothorn LA (2008): Joint one-sided and two-sided simultaneous confidence intervals, Journal of Biopharmaceutical Statistics. 18(2):293-306

Dilba G, Hothorn LA, Tsong Y (2008): Equivalence Tests for Shelf Life and Average Drug Content in Stability Studies, Journal of Biopharmaceutical Statistics 18:985-995

Froemke C, Hothorn LA, Kropf S (2008): Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizes, BMC Bioinformatics 9:54

Hasler M and Hothorn LA (2008): Multiple Contrast Tests in the Presence of Heteroscedasticity, Biometrical Journal 50:793-800

Hasler M, Vonk R, Hothorn LA (2008): Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticity, Statistics in Medicine 27:490-503

Hothorn LA and Hasler M (2008): Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control, Journal of Biopharmaceutical Statistics 18:915-933

Hughes S (2008): European regulatory agencies should employ full time statisticians, British Medical Journal 336(7638):250

Rauschen S, Eckert J, Schaarschmidt F, Schuphan I, Gathmann A (2008): An evaluation of methods for assessing the impacts of Bt-maize MON810 cultivation and pyrethroid insecticide use on Auchenorrhyncha (Planthoppers and Leafhoppers), Agricultural and Forest Entomology 10:331-339

Schaarschmidt F, Sill M, Hothorn LA (2008): Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast test, Journal of Biopharmaceutical Statistics 18:934-948

Schaarschmidt F, Sill M, Hothorn LA (2008): Approximate Simultaneous Confidence Intervals for Multiple Contrasts of Binomial Proportions, Biometrical Journal 50:782-792

Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson JR, Erdmann J, Ziegler A, Samani NJ; Cardiogenics Consortium (2008): Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease, Circulation 117(13):1675-1684

Dilba G, Schaarschmidt F, Hothorn LA (2007): Inferences for ratios of normal means, R News 7(1):20-23

Hothorn LA (2007): How to deal with multiple treatment or dose groups in randomized clinical trials?, Fundamental & Clinical Pharmacology 21(2):137-154

Schaarschmidt F (2007): Experimental design for one-sided confidence intervals or hypothesis tests in binomial group testing, Communications in Biometry and Crop Science 2(1):32-40.

Toschki A, Hothorn LA, Ross-Nickoll M (2007): Effects of cultivation of genetically modified Bt maize on epigeic arthropods, Environmental Entomology 36(4):967-981

Dilba G, Bretz F, Hothorn LA, Guiard V (2006): Power and sample size computations in simultaneous tests for non-inferiority based on relative margins, Statistics in Medicine 25(7):1131-1147

Eckert J, Schuphan L, Hothorn LA, Gathmann A (2006): Arthropods on Maize Ears for Detecting Impacts of Bt Maize on Nontarget Organisms, Environmental Entomology 35:554-560

Gathmann A, Wirooks L, Hothorn LA, Bartsch D, Schuphan I. (2006): Impact of Bt maize pollen (MON810) on lepidopteran larvae living on accompanying weeds, Molecular Ecology 15(9):2677-2685

Hauschke D and Hothorn LA (2006): Letter to Editor: An introductory note to the CHMP guidelines: choice of the non-inferiority margin and data monitoring committees by David Brown, Peter Volkers and Simon Day, Statistics in Medicine 25:1623-1627; Statistics in Medicine 26:230-236

Hothorn LA (2006): Statistical analysis of in vivo anticancer experiments: Tumor growth inhibition, Drug Information Journal 40:229-238

Hothorn LA (2006): Multiple comparisons and multiple contrasts in randomized dose-response trials - confidence interval orient approaches, Journal of Biopharmaceutical Statistics 16:711-731

Hothorn LA and Bleiholder H (2006): Statistical effects of efficacy evaluation of plant protection products in field trials- a comment to EPPO standard PP1/152, EPPO Bulletin 36:31-45

Hothorn LA and Oberdörfer R (2006): Statistical analysis used in the nutritional assessment of novel food using the proof of safety, Regulatory Toxicology and Pharmacology 44:125-135

Neuhäuser M, Hothorn LA (2006): A robust modification of the ordered-heterogeneity test, Journal of Applied Statistics

Hothorn LA (2005): Biostatistics in nonclinical and preclinical drug development, Biometrical Journal 47:282-285

Dilba G, Bretz F, Guiard V, Hothorn LA (2004): Simultaneous confidence intervals for ratios with application to the comparison of several treatments with a control, Methods of Information in Medicine 43:465-469

Hothorn LA and Bauss F (2004): Biostatistical design and analyses of long-term animal studies simulating human postmenopausal osteoporosis, Drug Information Journal 38:47-56

Neuhäuser M, Buening H, Hothorn LA (2004): Maximum test versus adaptive tests for the two-sample location problem, Journal of Applied Statistics 31(2):215-227

Biesheuvel E and Hothorn LA (2003): Protocol designed subgroup analyses in multiarmed clinical trials: multiplicity aspects, Journal of Biopharmaceutical Statistics 13:663-673

Bretz F and Hothorn LA (2003): Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays, ATLA: Alternatives to Lab Animals 31(1):81-96

Bretz F, Hothorn LA, Hsu J (2003): Identifying effective and/or safe doses by stepwise confidence intervals for ratios, Statistics in Medicine 22:847-858

Hauschke D and Hothorn LA (2003): Two-stage testing of safety: A statistical view, ATLA: Alternatives to Lab Animals 31(1):77-80

Hirotsu C and Hothorn LA (2003): Impact of the ICH E9 guideline: statistical principles for clinical trials on the conduct of clinical trials in Japan, Drug Information Journal 37:381-396

Hothorn LA (2003): Statistics of interlaboratory in vitro toxicological studies, ATLA: Alternatives to Lab Animals 31(1):43-63

Hothorn LA and Bretz F (2003): Dose-response and thresholds in mutagenicity studies: A statistical testing approach, ATLA: Alternatives to Lab Animals 31(1):97-103

Hothorn LA and Wassmer G (2003): Analyzing randomized dose finding studies with a primary and a secondary endpoint, Journal of Biopharmaceutical Statistics 13:301-305

Neuhäuser M, Leisler B, Hothorn LA (2003): A trend test for the analysis of multiple paternity, Journal of Agricultural, Biological, and Environmental Statistics 8:29-35

Bauss F, Lalla S, Endele R, Hothorn LA (2002): The effects of treatment with ibandronate on bone mass, architecture, biomechanical properties and bone concentration of ibandronate in ovariectomized aged rats, Journal of Rheumatology 29(10):2200-2208

Bauss F, Wagner M, Hothorn LA (2002): Total administered dose of Ibandronate determines its effect on bone mass, Journal of Rheumatology 29:990-998

Biesheuvel E and Hothorn LA (2002): Many-to-one comparisons in stratified designs, Biometrical Journal 44:101-116

Bretz F and Hothorn LA (2002): Detecting dose–response using contrasts: asymptotic power and sample size determination for binomial data, Statistics in Medicine 21:3325-3335

Hothorn LA (2002): Selected biostatistical aspects of the validation of in vitro toxicological assays, ATLA: Alternatives to Lab Animals 30(2):93-98

Schulte A, Althoff J, Ewe S, Richter-Reichhelm HB; BGVV Group Investigators (2002): Two immunotoxicity ring studies according to OECD TG 407-comparison of data on cyclosporin A and hexachlorobenzene, Regulatory Toxicology and Pharmacology 36(1):12-21

Weichert M and Hothorn LA (2002): Robust hybrid tests for the two-sample location problem, Communications in Statistics - Simulation and Computation 31:175-187

Bauer P, Hothorn LA, Westfall P (2001): Special issue multiple comparison procedures, Biometrical Journal 43:531

Bretz F and Hothorn LA (2001): Testing dose-response relationships with a priori unknown possibly nonmonotone shapes, Journal of Biopharmaceutical Statistics 11:193-207

Bretz F, Genz A, Hothorn LA (2001): On the numerical availibilty of multiple comparison procedures, Biometrical Journal 43:645-656

Munzel U and Hothorn LA (2001): An unified approach to simultaneous rank test procedures in the unbalanced one-way layout, Biometrical Journal 43:553-559

Tamhane AC and Hothorn LA (2001): Letter to the editor: A multiple comparison procedure for the three and four-armed controlled clinical trials, Statistics in Medicine 20:317-321

Bretz F and Hothorn LA (2000): A powerful alternative to Williams' test with application to toxicological doseresponse relationships of normally distributed data, Environmental and Ecological Statistics 7:135-154

Hothorn LA and Bretz F (2000): Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast tests, Biometrical Journal 42:553-567

Hothorn LA and Bretz F (2000): One-sided simultaneous confidence intervals for effective dose steps in unbalanced designs, Biometrical Journal 42:995-1006

Hothorn LA and Hauschke D (2000): Identifying the maximum safe dose: a multiple testing approach, Journal of Biopharmaceutical Statistics 10:15-30

Hothorn LA, Hayashi M, Seidel D (2000): Dose-response relationships in mutagenicity assays including an appropriate positive control group: a multiple testing approach, Environmental and Ecological Statistics 7:27-42

Lehmacher W, Kieser M, Hothorn LA (2000): Sequential and multiple testing for dose-response analysis, Drug Information Journal 34:591-597

Neuhäuser M and Hothorn LA (2000): Parametric location-scale and scale trend tests based on Levene’s transformation, Computational Statistics and Data Analysis 33:189-200

Neuhäuser M, Seidel D, Hothorn LA (2000): Robust trend tests with application to toxicology, Environmental and Ecological Statistics 7:43-56

Hauschke D, Kieser M, Hothorn LA (1999): Proof of safety in toxicology based on the ratio of two means for normally distributed data, Biometrical Journal 41:295-304

Hothorn LA (1999): Trend tests in epidemiology: p-values or confidence intervals?, Biometrical Journal 41:817-825

Koch H-F and Hothorn LA (1999): Exact unconditional distributions for dichotomous data in many-to-one comparisons, Journal of Statistical Planning and Inference 82(1-2):83-99

Neuhäuser M and Hothorn LA (1999): An exact Cochran-Armitage test for trend when dose-response shapes are a priori unknown, Computational Statistics and Data Analysis 30:403-412

Bauer P, Röhmel J, Maurer W, Hothorn LA (1998): Testing strategies in multi-dose experiments including active control, Statistics in Medicine 17(18):2133-2146

Bolte R, Walz M, Lehmann KJ, Hothorn T, Brill C, Hothorn LA, Georgi M (1998): Teleradiology: results of a questionnaire of German radiologists, Journal of Telemedicine and Telecare 4 Suppl 1:69-71

Fairweather WR, Bhattacharyya A, Ceuppens PP, Heimann G, Hothorn LA, Kodell RL, Lin KK, Mager H, Middleton BJ, Slob W, Soper KA, Stallard N, Ventre J, Wright J (1998): Biostatistical Methodology in Carcinogenicity Studies, Drug Information Journal 32:401-421

Lalla S, Hothorn LA, Haag N, Bader R, Bauss F (1998): Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats, Osteoporosis International 8(2):97-103

Neuhäuser M and Hothorn LA (1998): An analogue of Jonckheere’s trend test for parametric and dichotomous data, Biometrical Journal 40:11-19

Neuhäuser M, Liu P-Y, Hothorn LA (1998): Nonparametric tests for trend: Jonckheere’s test, a modification and a maximum test, Biometrical Journal 40:899-909

Hothorn LA (1997): Modifications of the closure principle for analyzing toxicological studies, Drug Information Journal 30(2):403-412

Hothorn LA and Martin U (1997): Application of adaptive interim analysis in pharmacology, Drug Information Journal 30(2):615-619

Hothorn LA, Lin KK, Hamada C, Rebel W (1997): Recommendations for Biostatistics of Repeated Toxicity Studies, Drug Information Journal 30(2):327-334

Hothorn LA, Neuhäuser M, Koch H-F (1997): Analysis of randomized dose-finding studies: closure test modifications based on multiple contrast tests, Biometrical Journal 39:467-479

Kropf S, Hothorn LA, Läuter J (1997): Multivariate many-to-one procedures with applications to pre-clinical trials, Drug Information Journal 30(2):433-447

Neuhäuser M and Hothorn LA (1997): The control of consumer’s risk in the Ames mutagenicity assay, Drug Information Journal 30(2):363-367

Neuhäuser M and Hothorn LA (1997): Trend tests for dichotomous endpoints with application in carcinogenicity studies, Drug Information Journal 30(2):463-469

Hauschke D, Steinjans VW, Hothorn LA (1996): A note on Welch’s approximate t-solution to bioequivalence assessment, Biometrika 83:236-237

Hothorn LA (1994): Multiple Comparisons in Long-Term Toxicity Studies, Environmental Health Perspectives 102 Suppl 1:33-38

Hothorn LA (1994): Biostatistical analysis of the micronucleus mutagenicity assay based on the assumption of a mixing distribution, Environmental Health Perspectives 102 Suppl 1:121-125

Hothorn LA and Hajian G (1994): Biostatistical Aspects of Toxicokinetics, Drug Information Journal 28:187-190